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Taylor Dispersion Injections (TDi™)

In Taylor Dispersion Injections, dispersion is exploited to generate an analyte concentration gradient that provides a high-resolution dose response in a single injection for enhanced biophysical characterization and increased throughput. Analyte gradients conform to Taylor dispersion theory for accurate modeling of the analyte concentration during the titration. A full analyte titration over 3-4 orders of magnitude in concentration is recorded within a few minutes. The technique also provides an absolute method for determination of the analyte diffusion coefficient and can be used to assess whether the analyte is heterogeneous or aggregated - valuable information in method development.

Whitepaper

Download the paper TDi for Complex Binding

Publications

(Free Download) Evaluation of Taylor dispersion injections: Determining kinetic/affinity interaction constants and diffusion coefficients in label-free biosensing, John G. Quinn, Analytical Biochemistry (2011) doi:10.1016/j.ab.2011.11.023

Modeling Taylor dispersion injections: Determination of kinetic/affinity interaction constants and diffusion coefficients in label-free biosensing, John G. Quinn, Analytical Biochemistry (2011) doi:10.1016/j.ab.2011.11.024